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pentobarbital will lessen the level or result of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to your minimize in fentanyl plasma concentrations, lack of efficacy or, perhaps, development of a withdrawal syndrome in the pat